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Sofosbuvir

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What is Sofosbuvir?

Sofosbuvir, sold under the brand name Sovaldi, is an antiviral drug used for treating hepatitis C. It belongs to the nucleotide analog family and treats hepatitis C by blocking the NS5B protein, the main compound for HCV replication.

Product Description:

Molar Mass: 529.458 g·mol−1
SMILES: CC(C)OC(=O)[C@H](C)N[P@](=O)(OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@](C)(F)[C@@H]1O)OC3=CC=CC=C3
InChIKey: TTZHDVOVKQGIBA-IQWMDFIBSA-N
ALogP: 1.66
CAS Number: 1190307-88-0
Chemical Formula: C22H29FN3O9P
Therapeutic Category: Antiviral
Form: Tablet
Assay: NLT 99.0%
Storage: Suitable temp for storage is -20C. Protect from humidity; keep in a dry, cool, and shady place.
Suitable for: Adults, Elderly People
Application: Sofosbuvir is a fixed-dose combination drug with multiple medicines to treat various liver-related diseases.
IUPAC Name:
Isopropyl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyl-tetrahydrofuran-2-yl]methoxy-phenoxy-phosphoryl]amino]propanoate. The chemical structure of Sofosbuvir is shown below:

Approved Indication (2)

As per the clinical trials from 1-4, there are two approved indications of Sofosbuvir:

  • Hepatitis C
  • Hepatitis C, Chronic

Experimental Indication (53)

Besides the main indication, Sogfosbuvir can also be used in the experimentation process for:

  • beta-Thalassemia (Phase 4)
  • Bone Diseases, Metabolic (Phase 4)
  • Buprenorphine (Phase 4)
  • Carcinoma, Hepatocellular (Phase 4)
  • Coinfection (Phase 4)
  • COVID-19 (Phase 4)
  • Cryoglobulinemia (Phase 2/Phase 3)
  • Drug Misuse (Phase 4)
  • Drug-Related Side Effects and Adverse Reactions (Phase 4)
  • Fibrosis (Phase 4)
  • Gaucher Disease (Phase 4)
  • Healthy Volunteers (Phase 1)
  • Heart Failure (Phase 4)
  • Hematologic Neoplasms (Phase 1/Phase 2)
  • Hematopoietic Stem Cell Transplantation (Phase 4)
  • Hepacivirus (Phase 3)
  • Hepatitis (Phase 1)
  • Hepatitis B (Phase 3)
  • Hepatitis B, Chronic (Phase 4)
  • Hepatitis C ()
  • Hepatitis C, Chronic ()
  • Hepatitis, Chronic (Phase 2)
  • Hepatitis E (Phase 2)
  • HIV (Phase 4)
  • HIV Infections (Phase 4)
  • Hypertension, Portal (Phase 2)
  • Insulin Resistance (Phase 4)
  • Kidney (Phase 4)
  • Kidney Failure, Chronic (Phase 4)
  • Kidney Transplantation (Phase 3)
  • Liver (Phase 2)
  • Liver Cirrhosis (Phase 4)
  • Liver Diseases (Phase 4)
  • Liver Transplantation (Phase 4)
  • Lung Diseases (Phase 1/Phase 2)
  • Lung Diseases, Interstitial (Phase 4)
  • Lung Transplantation (Phase 1)
  • Lymphoma (Phase 2)
  • Lymphoma, B-Cell (Phase 2)
  • Metabolic Syndrome (Phase 2/Phase 3)
  • Methadone (Phase 4)
  • Neoplasms (Phase 4)
  • Opioid-Related Disorders (Phase 4)
  • Organ Transplantation (Phase 4)
  • Pharmacology (Phase 4)
  • Pregnancy (Phase 1)
  • Pregnancy Complications (Phase 4)
  • Pulmonary Disease, Chronic Obstructive (Phase 4)
  • Renal Insufficiency (Phase 4)
  • Respiratory Insufficiency (Phase 4)
  • Severe Acute Respiratory Syndrome (Phase 2)
  • Substance Abuse, Intravenous (Phase 3)
  • Thalassemia (Phase 4)

Clinical Trial (336)

A total of 336 trials took place in four phases. 206 companies took part in the trial process of the Sofosbuvir drug.

Side Effects

The common side effects seen with the consumption of Sofosbuvir are:

  • Fatigue
  • Headache
  • Troubled Sleep
  • Nausea

Conclusion

Sofosbuvir is an antiviral drug widely used to treat hepatitis C and other liver-related diseases. It belongs to the nucleotide polymerase inhibitors family and blocks the replication of the hepatitis C virus. You can easily control HCV replication in your body by taking a 400 mg tablet of Sofosbuvir once a day. Some common side effects that may be seen with the intake of Sofosbuvir are headache, irritation, itching, dizziness, and nausea.

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